List of Famous people who are 45

Ryan Rodney Reynolds is a Canadian-American actor, film producer, and entrepreneur. He began his career starring in the Canadian teen soap opera Hillside (1991–1993), and had minor roles before landing the lead role on the sitcom Two Guys and a Girl between 1998 and 2001. Reynolds then starred in a range of films, including comedies such as National Lampoon's Van Wilder (2002), Waiting... (2005), and The Proposal (2009). He also performed in dramatic roles in Buried (2010), Woman in Gold (2015), and Life (2017), starred in action films such as Blade: Trinity (2004), Deadpool (2016), and 6 Underground (2019) and provided voice acting in the animated features The Croods (2013), Turbo (2013), and Pokémon: Detective Pikachu (2019).

Jack Patrick Dorsey is an American technology entrepreneur and philanthropist who is the co-founder and CEO of Twitter, and the founder and CEO of Square, a financial payments company.

Benedict Timothy Carlton Cumberbatch is an English actor. A graduate of the Victoria University of Manchester, he continued his training at the London Academy of Music and Dramatic Art, obtaining a Master of Arts in Classical Acting. He first performed at the Open Air Theatre, Regent's Park in Shakespearean productions and made his West End debut in Richard Eyre's revival of Hedda Gabler in 2005. Since then, he has starred in the Royal National Theatre productions After the Dance (2010) and Frankenstein (2011). In 2015, he played the title role in Hamlet at the Barbican Theatre.

Laura Jeanne Reese Witherspoon is an American actress, producer, and entrepreneur. The recipient of various accolades, including an Academy Award, two Golden Globe Awards, and a Primetime Emmy Award, she is one of the highest-paid actresses in the world as of 2019. Time magazine named her one of the 100 most influential people in the world in 2006 and 2015, and Forbes listed her among the World's 100 Most Powerful Women in 2019.

Kyrsten Lea Sinema is an American politician serving as the senior United States Senator from Arizona since January 2019. A member of the Democratic Party, she served three terms as a state representative for Arizona's 15th legislative district from 2005 to 2011, one term as the state senator for Arizona's 15th legislative district from 2011 to 2012, and three terms as the United States Representative for Arizona's 9th congressional district from 2013 to 2019.

Peyton Williams Manning is a former American football quarterback who played in the National Football League (NFL) for 18 seasons. Considered to be one of the greatest quarterbacks of all time, he spent 14 seasons with the Indianapolis Colts and four seasons with the Denver Broncos. Manning played college football for the University of Tennessee, leading the Tennessee Volunteers to the 1997 SEC Championship Game in his senior season. He is the second son of former NFL quarterback Archie Manning and older brother of former NFL quarterback Eli Manning. Nicknamed "The Sheriff" due to his tendency to audible prior to the snap, Manning is one of the most recognizable and parodied players in the NFL. Teams led by Manning typically used the hurry-up offense in place of the standard huddle.

Anna Kay Faris is an American actress, producer, podcaster, and author. She rose to prominence for her work in comedic roles, particularly the lead part of Cindy Campbell in the Scary Movie film series (2000–2006). Faris has appeared in a number of films, including The Hot Chick (2002), May (2002), Lost in Translation (2003), Brokeback Mountain (2005), Just Friends (2005), My Super Ex-Girlfriend (2006), Smiley Face (2007), The House Bunny (2008), What's Your Number? (2011), The Dictator (2012), and Overboard (2018). On television, she had a recurring role as Erica, the birth mother to Monica Geller and Chandler Bing's twins in the final season of the NBC sitcom Friends (2004). From 2013 to 2020 Faris starred as Christy Plunkett on the CBS sitcom Mom.

Cillian Murphy is an Irish actor. He began his career performing as a rock musician. After turning down a record deal, he began his acting career in theatre, and in short and independent films in the late 1990s. His first notable film roles include Darren in Disco Pigs (2001), Jim in 28 Days Later (2002), John in Intermission (2003), Jackson Rippner in Red Eye (2005), and Patrick "Kitten" Braden in Breakfast on Pluto (2005). For Breakfast on Pluto, he was nominated for a Golden Globe Award for Best Actor in a Musical or Comedy, and won an Irish Film and Television Award for Best Actor. Murphy is known for his collaborations with director Christopher Nolan, playing the Scarecrow in Christopher Nolan's The Dark Knight Trilogy (2005–2012); as well as appearing in Inception (2010) and Dunkirk (2017).

Kim Joo-ryoung is a South Korean actress.

Eldrick Tont "Tiger" Woods is an American professional golfer. He is tied for first in PGA Tour wins and ranks second in men's major championships and also holds numerous golf records. Woods is widely regarded as one of the greatest golfers, and one of the most famous athletes of all time. He will be inducted into the World Golf Hall of Fame in 2021.